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Editor's e-Note
Each year, SNMMI’s Image of the Year exemplifies cutting-edge molecular imaging and provides a peek at how the still-emerging field will improve the detection and treatment of disease in patients. It will take some years until large numbers of molecular imaging developments find their way into routine clinical use, but it becomes clearer each year that it will happen. This year’s Image of the Year is no exception.

— Jim Knaub, editor
e-News Exclusive
PET Tracer for Alzheimer’s Provides Image of the Year

A PET image using F-18 THK5117, a novel tracer that labels neurofibrillary tangles with hyperphosphorylated tau deposition found in Alzheimer’s disease patients’ brains, was named the Image of the Year at SNMMI’s 2014 annual meeting in St Louis.

The tau/neurofibrillary tangles are one of two distinct pathological changes seen in Alzheimer's disease patients’ brains; the other change is the presence of amyloid plaques. Other tracers, such as 11C-PiB and florbetapir F18, are designed to bind to amyloid plaques. Radiotracers that bind to tau/neurofibrillary tangles, such as F-18 THK5117, still are under development.

In the study at Tohoku University School of Medicine in Japan, Nobuyuki Okamura, MD, PhD, and his team had eight AD patients and six age-matched healthy control subjects undergo F-18 THK5117 PET scans for 90 minutes. PET scans were performed with C-11 PiB on the same population. Standard uptake value ratios were calculated 60 to 80 minutes postinjection for THK5117 and 40 to 70 minutes postinjection for PiB using the cerebellar cortex as the reference region. Partial volume correction, accounting for both gray matter atrophy and white matter spillover, was performed using PMOD 3.4 quantitative imaging processing software.

"In this study, the selective binding ability of F-18 THK5117 to tau was confirmed by the direct comparison with the amyloid PET tracer PiB," Okamura said. "I hope that this technique will contribute to the development of new antidementia drugs.”

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In This e-Newsletter
Worth Repeating
“As the landscape shifts and people are more in charge of their health care in terms of spending more of their money on rising insurance premiums and deductibles and being empowered by access to information that allows them to distinguish among providers, those ancillary things are starting to matter more.”

Jonathan W. Berlin, MD, MBA, FACR,
a clinical professor of radiology at NorthShore University HealthSystem in suburban
Chicago, in an ACR press release
about patient satisfaction
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A New Option
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Reporter’s Notebook: ARRS 2014
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Other Imaging News
New Improved Radiotracer Methods
Researchers at Princeton University are finding ways to improve radiotracers by avoiding existing methods, which require harsh conditions that may affect the radiotracers’ more delicate chemical bonds, Medical News Today reports.

DTI Examines Brain, Identifies Concussion Risks
Advanced diffusion tensor imaging measures changes in the brain structure, potentially identifying the risks associated with a concussion, according to an RSNA press release.

Imaging May Aid in Predicting MS Progression
MR spectroscopy provides measurements that may predict disability progression in multiple sclerosis patients, MedPage Today reports.

Gadavist: MR Contrast Agent for Breast Cancer Evaluation
Bayer HealthCare has announced that the FDA has cleared a new indication for Gadavist, making it the first MR contrast agent for breast cancer evaluation in the United States, according to its press release.
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Radiology Supervisor CT/MRI
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