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Radiology Today
E-Newsletter    April 2023
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Editor's E-Note

Among the many complications of COVID-19, one of the least understood is the mechanism behind some people’s loss of smell. Researchers in the United Kingdom attempted to understand the phenomenon better with MRI. Their conclusions offer hope for those suffering from long COVID who have not regained their sense of smell. For more details, check out our e-News Exclusive.

Is your facility seeing many patients with long COVID? Let us know on Twitter and/or Facebook.

Enjoy the newsletter.

— Dave Yeager, editor
In This E-Newsletter

E-News Exclusive
Long COVID Smell Loss Linked to Brain Changes

People living with long COVID who suffer from loss of smell show different patterns of activity in certain regions of the brain, a new study has found. The research used MRI scanning to compare the brain activity of people with long COVID who lost their sense of smell, those whose smell had returned to normal after COVID infection, and people who had never tested positive for COVID-19.

Published in eClinicalMedicine, the observational study found that people with long COVID smell loss had reduced brain activity and impaired communication between two parts of the brain that process important smell information: the orbitofrontal cortex and the prefrontal cortex. This connection was not impaired in people who had regained their sense of smell after COVID.


The findings suggest smell loss, known as anosmia, caused by long COVID is linked to a change in the brain that stops smells from being processed properly. Because it’s clinically reversible, as shown in some subjects, it may be possible to retrain the brain to recover its sense of smell in people suffering the side effects of long COVID.

Jed Wingrove, PhD, of the division of medicine at University College London and lead author of the study, says, “Persistent loss of smell is just one way long COVID is still impacting people’s quality of life. Smell is something we take for granted, but it guides us in lots of ways and is closely tied to our overall wellbeing. Our study gives reassurance that, for the majority of people whose sense of smell comes back, there are no permanent changes to brain activity.”

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Qualities of TIRADS Categories Reveal Malignancy
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Worth Repeating
“The PSG score can enable better stratification of patients based on the response to 177Lu-PSMA therapy and will assist individual clinical decision-making. These findings will be valuable in advancing precision medicine in the theranostics field.”

— Jeremie Calais, MD, MSc, an associate professor and director of the Clinical Research Program of the Ahmanson Translational Theranostics Division, on a new PSMA PET scoring system that determines if mCRPC patients respond to Lu-PSMA therapy
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